March

Date: Thursday, March 9th
Time: 4pm
Location: HNB small conference room (we’re back to the same ol’ spot)
Speaker: Monica Padilla
Paper: Verghese P, McKee SP. Motion grouping impairs speed discrimination Vision Res. 2006 Apr;46(8-9):1540-6. Epub 2005 Sep 13.

Discriminating between two speed signals is harder when they are seen as part of a single trajectory, compared to the case when they appear as distinct entities. Observers were asked to judge which half of a display had dots that were moving faster. This was done under two main conditions: when dot motion appeared to continue across the boundary between the two halves, and when it moved parallel to the boundary. Speed discrimination thresholds were elevated when motion in the two halves appeared to cross the boundary compared to the case when motion was parallel to the boundary. Extensive practice improved performance until speed discrimination in the two cases was virtually indistinguishable. The addition of noise caused the original effect to reappear, i.e., thresholds were elevated when motion continued across the border. Our results suggest that the local differences in velocity on either side of border are ignored when motion appears to cross the border. Instead the visual system seems to enforce an a priori assumption that when motion continues across a boundary it belongs to a common motion path.

Date: Thursday, March 23rd
Time: 4pm
Location: HNB small conference room
Speaker: David Merwine
Paper: Maximov V, Maximova E, Maximov P Direction Selectivity in the Goldfish Tectum Revisited Ann N. Y. Acad Sci 1048: 198-205 (2005)

Responses of direction-selective (DS) ganglion cells (GCs) were recorded extracellularly from their axon terminals in the superficial layer of the tectum opticum (TO) of immobilized goldfish, Carassius auratus gibelio (Bloch). Directional tuning curves were measured with contrast edges moving in 12 or more different directions across the receptive field (RF). All directional tuning curves had cardioid-like appearance, their acceptance angles amounted to somewhat more than 180 degrees . According to their preferred directions DS GCs proved to comprise three distinct groups, each group containing DS GCs of ON and OFF subtypes approximately in equal quantity. Thus, this gives six physiological types of DS GCs in total. The preferred direction of a DS GC does not depend to some extent on a value of contrast, speed, size, and form of the stimuli. Coincidence in number of preferred directions with number of semicircular canals implies that DS GCs projecting to tectum are involved in some multimodal sensory integration in postural, locomotor, and oculomotor control in the three-dimensional aquatic world. DS neurons of the TO itself respond independently of the sign of stimulus contrast, have enormous receptive fields, and seem likely to collect signals from the retinal DS units of both ON and OFF subtypes with the same preferred direction.

Date: Thursday, March 30th
Time: 4pm
Location: HNB small conference room
Speaker: Jeff Begley
Paper: Sergev R, Puchalla J, Berry MJ Functional organization of ganglion cells in the salamander retina J Neurophysiol. 2006 Apr;95(4):2277-92. Epub 2005 Nov 23.

Recently, we reported a novel technique for recording all of the ganglion cells in a retinal patch and showed that their receptive fields cover visual space roughly 60 times over in the tiger salamander. Here, we carry this analysis further and divide the population of ganglion cells into functional classes using quantitative clustering algorithms that combine several response characteristics. Using only the receptive field to classify ganglion cells revealed six cell types, in agreement with anatomical studies. Adding other response measures served to blur the distinctions between these cell types rather than resolve further classes. Only the biphasic off type had receptive fields that tiled the retina. Even when we attempted to split these classes more finely, ganglion cells with almost identical functional properties were found to have strongly overlapping spatial receptive fields. A territorial spatial organization, where ganglion cell receptive fields tend to avoid those of other cells of the same type, was only found for the biphasic off cell. We further studied the functional segregation of the ganglion cell population by computing the amount of visual information shared between pairs of cells under natural movie stimulation. This analysis revealed an extensive mixing of visual information among cells of different functional type. Together, our results indicate that the salamander retina uses a population code in which every point in visual space is represented by multiple neurons with subtly different visual sensitivities.